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Journal Article 1

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2020 1

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Dedifferentiation 1

Phosphoproteome 1

Primary hepatocytes 1

Proteome 1

Ubiquitination 1

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Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation Article

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Engineering 2020, Volume 6, Issue 11,   Pages 1302-1314 doi: 10.1016/j.eng.2020.02.011

Abstract: To elucidate the underlying mechanisms that induce dedifferentiation, we carried out parallel quantificationsWe revealed a low correlation between the transcriptome and WCP during dedifferentiation.A combined analysis of the ubiquitinome with the corresponding WCP indicated that the dedifferentiationTaken together, our data provide new insights into proteome dynamics during PHC dedifferentiation andpotential targets to inhibit the dedifferentiation process.

Keywords： Ubiquitination     Phosphoproteome     Proteome     Dedifferentiation     Primary hepatocytes    

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Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Journal Article